Information on distribution, abundance and size composition of the two octopods Eledone cirrhosa and E. moschata was obtained from the MEDITS trawl surveys, carried out in a wide area of the Mediterranean basin from 1994 to 1999. Both species showed a wide geographic distribution, as they were collected in all the major areas investigated. E. cirrhosa showed a wide depth distribution, down to the 800 m isobath, while E. moschata was mostly restricted to within 200 m. Further analysis on spatio-temporal basis with a Generalised Linear Model, evidenced that differences among major areas, depth strata and their interaction were always significant. In the case of E. cirrhosa, differences among years and year-major area interaction were also significant. Two cohorts can be singled out in the size frequency distributions of E. cirrhosa, whereas only one mode can be clearly distinguished in most of the length distributions of E. moschata.